Issue |
ESAIM: ProcS
Volume 45, September 2014
Congrès SMAI 2013
|
|
---|---|---|
Page(s) | 285 - 289 | |
DOI | https://doi.org/10.1051/proc/201445029 | |
Published online | 13 November 2014 |
Evolutionary paradigm in cancer immunology*
U.M.P.A, Ecole Normale Supérieure de
Lyon 46, allée
d’Italie, F69364
Lyon Cedex 07,
email: alexei.tsygvintsev@ens-lyon.fr
The dynamical system theory in combination with experimental medical data can serve to improve our understanding of how the immune system works and fights the cancer. Some recent mathematical models (see [1]) try to explain the complex interaction between tumor cells, immune-effector cells and both immunosuppressive and immunostimulating cytokines. In this paper the Kirschner-Panetta system [6] is considered. The objective of the study is to broaden, through evolutionary dynamics, our understanding of the efficiency of adoptive immunotherapy and also shed the light on the phenomena of spontaneous tumor remission.
Résumé
La théorie des systèmes dynamiques non linéaires en combinaison avec des données médicales expérimentales peut contribuer à notre compréhension comment le système immunitaire fonctionne et interagi avec le cancer. Les divers modèles mathématiques [1] décrivent l’interaction complexe entre les populations de cellules tumorales, de cellules immunitaires effectrices et des cytokines. Dans ce travail le système de Kirschner-Panetta [6] est analysé. L’objectif de ce travail est d’étudier, à travers de la dynamique évolutionnaire, l’efficacité de limmunotherapie adoptive et clarifier le phénomène de la régression spontanée.
© EDP Sciences, SMAI 2014
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